EGCG and the Inhibition of Cell Invasion


The aim of the present study was to investigate the inhibitory effects of the polyphenol epigallocatechin‑3‑gallate (EGCG) on migration capacity using in vitro-agarose spot assay and microRNAs profiling in MDA-MB-231, MCF-7, HeLa, and HEK-293 cell lines. The migration capacity of cells was significantly reduced. Immunfluorescencestaining showed no effect of EGCG on phospho-Profilin. The inhibitory effect of cell migration by EGCG could not be attributed to lower regulation of EGFR; EGCG had also no effect on CD29