EGCG and the Inhibition of Cell Invasion

Overview

The aim of the present study was to investigate the inhibitory effects of the polyphenol epigallocatechin‑3‑gallate (EGCG) on migration capacity using in vitro-agarose spot assay and microRNAs profiling in MDA-MB-231, MCF-7, HeLa, and HEK-293 cell lines. The migration capacity of cells was significantly reduced. Immunfluorescencestaining showed no effect of EGCG on phospho-Profilin. The inhibitory effect of cell migration by EGCG could not be attributed to lower regulation of EGFR; EGCG had also no effect on CD29